Prevalence and associated risk factors of Neospora caninum infection among cattle in mainland China: A systematic review and meta-analysis

Abstract

Neospora caninum, an intracellular protozoan, has attracted much attention because of the etiology of reproductive disorders in cattle. Although numerous relevant studies have been published, the overall prevalence of Neospora caninum infection among cattle in mainland China is still unknown, and associated risk factors need to be evaluated to establish preventive measures. We systematically searched four databases for epidemiologic studies that investigated the prevalence and associated risk factors of this parasite among cattle in mainland China. A total of 33,945 cattle from 51 studies were tested. The pooled prevalence of Neospora caninum among cattle in mainland China was 13.69% (95% CI: 10.86%−17.12%) through the random-effects model, which showed high heterogeneity, I2 = 98%. The analysis showed that Neospora infection-positive cows were 2.42 times more likely to abort than infection-negative cows (OR 2.42; 95% CI: 2.07–2.84). Our analysis indicated that Neospora-infection is widely distributed among cattle in China, which reinforces the importance of adequate prevention and control strategies to reduce economic losses for the cattle industry.