Prevalence and antibiogram of extended spectrum β-lactamase producing Klebsiella pneumoniae and Proteus mirabilis in clinical isolates

Abstract

Rapid emergence of ESBL production in bacteria like Klebsiella and Proteus species has put forward a major challenge in their detection as well as treatment options. This study was conducted from Oct 2012 to May 2015 to know the prevalence and antibiogram of ESBL producing Klebsiella pneumonia & Proteus mirabilis. Blood, sputum, pus, wound samples were collected and processed; identification of isolates was done as per standard methods. ESBL detection was done with double disk test and combination disk and confirmed with MIC reduction test. 208/578 (36.0%) &126/ 405 (31.1%) isolates of Klebsiella pneumoniae & Proteus mirabilis were ESBL producers respectively. The present study showed a high percentage of ESBL producers among clinical isolates of Klebsiella pneumoniae and Proteus mirabilis to frequently used antibiotics. Knowledge of antibiogram studies will help physicians in choosing an empirical treatment. To know the changing trends in resistance regular antibiotic susceptibility studies should be conducted. Key words: Extended spectrum beta lactamases (ESBL), Klebsiella pneumoniae, Proteus mirabilis, antibiogram, Resistance