Prevalance of Celiac Disease in Patients with Inflammatory Bowel Disease in Turkish Population.

Göksel Bengi,Ender Ellidokuz,Mesut Akarsu,Hale Akpınar,Musa Cıvak,Ömer Topalak,Müjde Soytürk

doi:10.1155/2019/6272098

Göksel Bengi, Ender Ellidokuz + Show 5 more

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https://doi.org/10.1155/2019/6272098

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Abstract

Background Celiac disease (CD) and inflammatory bowel disease (IBD) involve inflammation of the gastrointestinal lumen, which environmental, genetic, and immunological factors have a role in their pathogenesis. The prevalence of celiac disease in IBD ranges from 0% to 14%. In this study, our aim was to determine the prevalence of CD in IBD patients followed by us who are attending the hospital or outpatient clinic over a period of time of seven years. Methods Seven hundred and fifty nine patients (425 M, 334 F, mean age: 46.75, 396 ulcerative colitis (UC), 363 Crohn's disease (CrD)) diagnosed and followed up for IBD between January 2009 and July 2016 were evaluated retrospectively, and clinical, demographic, laboratory, and endoscopic data were collected. Results CD was investigated in 79 (%10.4) inflammatory bowel disease patients according to symptoms, and in 5.06% (n = 4) of them, we diagnosed CD. The most common indication for investigating for CD was iron deficiency anemia unreponsive to iron supplementation. Conclusions We did not find an increased prevalance of celiac disease in Turkish IBD patients in this study. In the presence of refractory iron deficiency anemia without any other cause in IBD patients, investigations for celiac disease should be considered.

Highlights

Celiac disease (CD), Crohn’s disease (CrD), and ulcerative colitis (UC) are inflammatory diseases of the gastrointestinal lumen with environmental, genetic, and immunologic factors playing a role in their pathogenesis
It is difficult to make the diagnosis of CD in patients previously diagnosed with inflammatory bowel disease (IBD) because symptoms of diarrhea, weight loss, and abdominal pain are common in both conditions and can be confusing
CD was detected in 0.52% of all IBD patients in the follow-up program and in 5.06% (n = 4) of 79 inflammatory bowel disease patients investigated for CD

Summary

Introduction

Celiac disease (CD), Crohn’s disease (CrD), and ulcerative colitis (UC) are inflammatory diseases of the gastrointestinal lumen with environmental, genetic, and immunologic factors playing a role in their pathogenesis. Celiac disease (CD) and inflammatory bowel disease (IBD) involve inflammation of the gastrointestinal lumen, which environmental, genetic, and immunological factors have a role in their pathogenesis. Seven hundred and fifty nine patients (425 M, 334 F, mean age: 46.75, 396 ulcerative colitis (UC), 363 Crohn’s disease (CrD)) diagnosed and followed up for IBD between January 2009 and July 2016 were evaluated retrospectively, and clinical, demographic, laboratory, and endoscopic data were collected. We did not find an increased prevalance of celiac disease in Turkish IBD patients in this study. In the presence of refractory iron deficiency anemia without any other cause in IBD patients, investigations for celiac disease should be considered

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