Abstract
Gastric ulcer are one of the most prevalent diseases in the world, the treatment are expensive and produce many side effects, so the research of new therapies are valuable. To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir (WK) on ulcer induction with HCL/ethanol. All pretreatments were maintained for 14 days. Male mice (C57BL/J6) were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group received vehicle; the lansoprazole (L) group received 30 mg/kg/day lansoprazole; the water kefir (WK15 and WK30) groups received WK at a dose of 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by ulcer area, ulcer index and ulcer reduction percentage. The antioxidant effects were quantified by measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), and catalase activity in the stomach.Pretreatment with WK at both doses exerted gastroprotection against HCL/ethanol ulcer induced similar to pretreatment with lansoprazole (ulcer area: C: 14477±6204; U: 127578±33260; L: 39958±13921; K15: 79357±23814; K30: 63252±22435 μm2. p<0.05). In addition, WK promoted decreased protein oxidation (C: 0.018±0.004; U: 0.036±0.004; L: 0.021±0.004; WK15: 0.014±0.006; WK30: 0.023±0.003 μM of chloramine T/mg of protein) and increased SOD activity (C: 21.75±8.16, U: 2.91±1.63, L: 27.27±2.97, WK15: 28.79±4.84, and WK30: 28.25±8.69 USOD/mg protein) and catalase activity (C: 5.73±1.63, U: 0.78±0.23, L: 4.29±1.21, WK15: 4.28±0.74, and WK30: 3.56±1.23 ΔEmin/mg protein−1).We conclude that pretreatment with water kefir for 14 days promotes increased antioxidant enzyme activity, preventing gastric lesions against HCl/ethanol ulcer model by maintaining antioxidant performance in gastric tissue.Support or Funding InformationThis work was partially financed by FAPES (#72662319) and UVV.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
