Abstract
Background and aim of study: Propofol is one of the most frequently used medications for inducing and maintaining anesthesia. However, propofol injection causes pain and discomfort in more than 70% of patients. This study was performed to determine the effect of magnesium sulfate on reducing pain at the onset of anesthesia induced by propofol injection.
 Materials and methods: A total of 80 healthy adult patients were selected in this study with either sex, scheduled for routine elective surgical procedure under general anesthesia. The patients enrolled were divided randomly into two groups of 40 patients each. Group I received 30 mg/kg of intravenous magnesium sulfate in 5 ml. Group II (placebo group) received 5ml of 0.9% intravenous normal saline 1 minute before propofol injection. The patients were asked to report their pain during injection of propofol. For all statistical tests, p<0.05 was taken to indicate a significant difference.
 Results: The incidence of pain experienced in magnesium sulfate group was 30% patients and in saline group was 60% patients, which is statistically significant p<0.05. The severity of POPI was also lower in magnesium sulfate group than the saline group (p<0.05). The incidence of mild and moderate pain in groups I versus group II was 22.5% versus 37.5% and 7.5% versus 22.5% respectively p<0.05. There was no severe pain recorded in any groups.
 Conclusion: Magnesium sulfate can be used before induction of anesthesia to reduce pain on propofol injection.
 Mediscope Vol. 6, No. 2: Jul 2019, Page 73-77
Highlights
There was no significant difference of Mean arterial pressure (MAP) and HR between magnesium sulfate and saline groups during pre-intubation or three minutes post-intubation period (p>0.05) (Table II)
The incidence of pain experienced in magnesium sulfate group was 30% patients and in group II was 60% patients, which is statistically significant p
The severity of propofol injection (POPI) was lower in magnesium sulfate group than the saline group (p
Summary
Propofol is one of the most popular intravenous anesthetic drugs. It has been used widely because of its numerous advantages including rapid induction and recovery and reducing postoperative nausea and vomiting. 2. Dr Md. Mamunur Rashid DA Associate Professor (cc) Department of anesthesiology Gazi Medical College. 4. Dr Md. Anisur Rahman Babu DA Medical officer, Department of anesthesiology. 5. Dr Afsana Sultana DA Medical officer, Department of anesthesiology. Anesthesiology Department of anesthesia, analgesia, palliative and Intensive care medicine Dhaka Medical College Hospital. This study was performed to determine the effect of magnesium sulfate on reducing pain at the onset of anesthesia induced by propofol injection. Group II (placebo group) received 5ml of 0.9% intravenous normal saline 1 minute before propofol injection. Results: The incidence of pain experienced in magnesium sulfate group was 30% patients and in saline group was 60% patients, which is statistically significant p
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