Abstract
Breast cancer is the second leading cause of cancer death in American women. Adjuvant radiotherapy (RT) following breast conservation surgery has significantly improved survival. However, about 30% of patients develop adverse skin reactions, pain, breast edema and poor cosmetic results that can impact quality of life. Inter-individual variability in the development of RT-induced adverse reactions in normal tissue is well-documented for both acute and late effects. Therefore, identifying individuals which may have severe reactions could assist the radiation oncologist in tailoring a treatment regimen which provides efficacy but minimal side effects.
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