Abstract
Dietary intake is understood to contribute to nutrition impact symptoms (NIS) in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to evaluate the performance of four a priori-defined diet quality indices on the presence of NIS 1 year following diagnosis using data on 323 participants from the University of Michigan Head and Neck Specialized Program of Research Excellence (UM-SPORE). Pretreatment dietary intake was measured before treatment initiation using a food frequency questionnaire. NIS were measured along seven subdomains. Multivariable binary logistic regression models were constructed to evaluate relationships between pretreatment scores on a priori-defined diet quality indices (AHEI-2010, aMED, DASH, and a low-carbohydrate score) and the presence of individual symptoms in addition to a composite “symptom summary score” 1-year postdiagnosis. There were several significant associations between different indices and individual NIS. For the symptom summary score, there were significant inverse associations observed for aMED (ORQ5-Q1: 0.36, 95% CI: 0.14–0.88, ptrend = 0.04) and DASH (ORQ5-Q1: 0.38, 95% CI: 0.15–0.91, ptrend = 0.02) and the presence of NIS 1-year postdiagnosis. Higher adherence to the aMED and DASH diet quality indices before treatment may reduce NIS burden at 1-year postdiagnosis.
Highlights
Introduction distributed under the terms andHead and neck squamous cell carcinoma (HNSCC) accounts for roughly 4% of all new cancer diagnoses in the United States [1]
There tended to be a higher proportion of females within the highest quintile of the diet quality indices compared to the lowest quintile
Proportions of current smokers tended to be higher within the lowest quintile of the examined indices and were most pronounced for AHEI-2010 and Dietary Approaches to Stop Hypertension (DASH), whereas former and never smoker proportions were higher in the highest quintiles of the aMED, AHEI-2010, and DASH
Summary
Introduction distributed under the terms andHead and neck squamous cell carcinoma (HNSCC) accounts for roughly 4% of all new cancer diagnoses in the United States [1]. HNSCC is commonly diagnosed in the oral cavity, oropharynx, hypopharynx, and larynx and is associated with lifetime exposure to tobacco and alcohol consumption and infection with particular strains of human conditions of the Creative Commons. In addition to symptomatology arising from tumor morphology and location, side effects that impact food and oral intake due to cancer treatment are highly prevalent in this population. Nutrition impact symptoms (NIS), as they are termed, include but are not limited to dysgeusia, ageusia, xerostomia, pain, dysphagia, dental problems, mucositis, and trismus [4]. An estimated 90% of HNSCC patients develop acute NIS due to their cancer treatment [5]. This symptom burden may perpetuate significant physical, emotional, and psychological issues, hampering the overall quality of life (QOL)
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