Prethodni prelomi kao prediktori nastanka osteoporoze

Abstract

Introduction: Fractures are often the first sign of osteoporosis. Aim: To establish importance of previous fractures as a predictor of osteoporosis. Material and Methods: The prospective analysis encompassed 2328 patients by merging two ,,Bonlink' databases from two reference osteodensitometric centers in Serbia: one from Special Hospital for Rheumatic Diseases Novi Sad and other from Railway Healthcare Center, Belgrade. All patients had their bone mineral density (BMD) measured at the lumbar spine and at the hip. Results were interpreted according to the valid definition of osteoporosis. All patients were questioned regarding previous low-trauma fractures and/or their radiographic findings were observed from medical documentation. In statistical analysis, descriptive statistics, central tendency measures, and chi-square test were used. Results: 97% of patients were women and 3% were men, with average 64.39±8.84 years of age. According to the T score of the hip and the lumbar spine, most patients had their BMD on the osteopenia and osteoporosis level. From all subjects, 31% had low energy fractures. Regarding differences between subjects with different T score at the hip and low energy fractures X2 = 60.19; p = 0.00) and differences between subjects with different T score at the lumbar spine and low energy fractures X2 = 31.89; p = 0.00) there was statistical difference between subjects with osteopenia/osteoporosis and those with regular Tscore results regarding previous low-trauma fractures (p<0.01). Conclusion: Low energy fractures are important predictor of osteoporosis. Therefore early diagnosis of osteoporosis is of utmost importance, before the first fracture occurs.