Preterm Neurodevelopmental Trajectories from 18 Months to 4.5 Years

Abstract

To assess the longitudinal trajectory of cognitive, language, and motor outcomes from 18months to 4.5years of age in children born very preterm. This was a prospective cohort study of 163 infants born very preterm (born 24-32weeks of gestation) followed longitudinally and assessed with neurodevelopmental scales and magnetic resonance imaging of the brain. Outcomes at 18months and 3years were assessed with the Bayley Scales of Infant and Toddler Development, 3rd Edition, and at 4.5years with the Wechsler Preschool and Primary Scale of Intelligence-III and the Movement Assessment Battery for Children. Cognitive, language, and motor outcomes were categorized as below-average, average, and above-average, and compared across time. Clinical data were analyzed using ANOVA, χ2 tests, and linear regression. Cognitive and language trajectories were stable from 18months to 4.5years for all outcome groups. Motor impairment increased over time, with a greater proportion of children having motor deficits at 4.5years. Children with below-average cognitive and language outcomes at 4.5years had more clinical risk factors, greater white matter injury, and lower maternal education. Children with severe motor impairment at 4.5years were born earlier, had more clinical risk factors, and demonstrated greater white matter injury. Children born preterm have stable cognitive and language trajectories, while motor impairment increased at 4.5years. These results highlight the importance of continued developmental surveillance for children born preterm into preschool age.