Preterm infants undergoing laparotomy for necrotizing enterocolitis or spontaneous intestinal perforation display evidence of impaired cerebrovascular autoregulation

Abstract

BackgroundPreterm infants requiring surgery are at risk of impaired neurocognitive development caused, possibly, by cerebral ischemia associated with impaired cerebrovascular autoregulation (CAR). We evaluated CAR before, during, and after laparotomy. Study designThis was a hypothesis generating prospective observational cohort study. SubjectsWe included preterm infants requiring surgery for necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP). Before, during, and after surgery we measured cerebral oxygen saturation using NIRS and calculated cerebral fractional tissue oxygen extraction (cFTOE). Outcome measuresImpaired CAR was defined if correlation coefficients (rho) between mean cFTOE and mean arterial blood pressure values were ≤−0.30 with P < .05. We used logistic regression analyses to determine factors associated with impaired CAR. ResultsNineteen infants with median (IQR) GA 27.6 weeks (26.6–31.0), birth weight 1090 g (924–1430), and postnatal age 9 days (7–12) were included. CAR was impaired more often during surgery than before (12 versus 3, P = .02) or after (12 versus 0, P < .01). A higher PCO2 level was associated with impaired CAR during surgery (OR 3.04, 95% CI, 1.11–8.12 for every 1 kPa increase). ConclusionsMore than half of preterm infants with NEC or SIP displayed evidence of impaired CAR during laparotomy. Further research should focus on mechanisms contributing to impaired CAR in preterm infants during surgery.