PRETERM BIRTH IS ASSOCIATED WITH INCREASED CENTRAL SYSTOLIC PRESSURE IN PRIMARY HYPERTENSION - SINGLE CENTER EXPERIENCE

Abstract

Objective: Preterm birth (PB) and lower birth weight (LBW) are associated with higher risk for hyprtension, chronic kidney disease and cardiovascular (CV) morbidity and mortality in adulthood. Our aim In this study was to analyze the association of PB and LBW with the parameters of arterial stiffness obtained during 24h measurement, with special focus on parameters of central hemodynamic (central aortic pressure). Design and method: In this study we included 154 adult patients (mean age 32, predominantly women (69.5%) with primary hypertension. In all of them we collected the data about term of birth and birth weight, and different antropological paramaters were measured. We determined various different laboratory data. Parameters of arterial stifness were measured in the office using Sphygmocor, and during the 24h using Mobil-o-Graph and Arteriograph. Results: In the whole group, 39 patients (25.5%) were born before the term. The corellation between pulse wave velocity (measured in office ambulatory during 24h) and term of birth was not found. The term of birth had low negative and statistically significant correlations with systolic central aortic pressure measured by Arteriograph during the night (r = -0.164, p < 0.05), as well as measured by Mobil-o-Graph during 24h (r = -0.167, p < 0.05), day (r = -0.172, p < 0.05) and night (r = -0.186, p < 0.05). Conclusions: Our findings suggest that preterm born is associated with increased systolic aortic pressure. We found this association fot the night time using two different devices. It could be speculated that this association might contribute to the global CV and kidney risk in subjects born before term. Further results are needed to answer whether ambulatory measurement of central hemodynamics have clinical importance.