Abstract
An action potential derived from the activity of presynaptic nerve endings can be recorded from the sympathetic ganglion of the rat. The purpose of this work is to demonstrate the precise relationship of this presynaptic spike with the excitatory postsynaptic potential (EPSP). The synaptic efficiency can be affected in three ways: (1) modifications of the quantity of the transmitter available, (2) modifications of the amount of the transmitter released by presynaptic nerve impulse, and (3) changes in the postsynaptic response to the transmitter. Calcium ions are a cofactor for the release of the transmitter, but after preganglionic stimulation, they also affect the quantity of the transmitter available later. The peculiar sensitivity of presynaptic endings is related to their huge surface-to-volume ratio and their high metabolic needs depending on an external energy supply. The early facilitation after activity and the effect of cesium chloride potentiate the transmission by increasing the size of presynaptic spikes.
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