Abstract
Some presynaptic cells in Helix pomatia possess serotonin and dopamine receptors, which are involved in the modulation of synaptic transfer. The serotonin antagonists tryptamine, 7-methyltryptamine, morphine, atropine, and methysergide decreased transmitter mobilization. 5-Methoxy-gramine, which is a selective inhibitor of hyperpolarizing serotonin responses, had no effect. The dopamine antagonists curare, chlorpromazine and haloperidol decreased transmitter mobilization, while ergometrine, flupenthixol, promethazine and 6-OH dopamine induced a small increase. The mechanisms are discussed and the properties of the presynaptic receptors are compared to the postsynaptic receptors. The usefulness of cell F76 in Helix brain as a model system for vertebrate brain function is discussed.
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