Abstract
The effect of saline extract of midgut from Oriental hornet ( Vespa orientalis) larvae on spontaneous and evoked release of acetylcholine at the frog sartorius neuromuscular junction was studied. The extract caused a 25–60% increase of the e.p.p. amplitude during the first 10–15 min, followed by a slow decrease, sometimes to below the control level. Neither the amplitude nor the size or shape of the miniature end-plate potentials changed. The changes in e.p.p. quantal content paralleled exactly the changes in the e.p.p. amplitude, which suggests that the activity of the extract is presynaptic.
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