Abstract
γ-Amino[2,3-3H]butyric acid ([3H]GABA) transport was investigated in hippocampal synaptosomes prepared from amygdala kindled rats. Kindling enhanced [3H]GABA uptake by 10–20%, while the Km of uptake and the kinetics of the release were unchanged. The dose response curve of the inhibition of [3H]GABA uptake by veratridine was altered by kindling: the K0.5 of inhibition and the Hill number increased and the curve became biphasic after a long period of stimulations. This effect was interpreted in terms of a modification of the functioning of the presynaptic fast Na+ channels which initially become more resistant to depolarization. In the long term, it appears that new Na+ channels develop that are more sensitive to the action of veratridine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
