Abstract
Purpose:With the advent of more aggressive cytotoxic chemotherapy regimens, the incidence of ocular toxicity due to these drugs is also on the rise. We report a case of Presumed Chemotherapy-Induced optic neuropathy and maculopathy secondary to treatment with cytarabine and daunorubicin for Acute Myeloid Leukaemia (AML).Case report:A 50-year-old man with AML developed sudden decrease in vision in his left eye after three cycles of chemotherapy with cytarabine and daunorubicin. He presented to us six weeks later with bilateral optic atrophy and foveal atrophic changes with early bull’s eye maculopathy. A diagnosis of presumed chemotherapy-induced optic neuropathy with maculopathy was made, and the patient was put on an alternative chemotherapeutic regimen. There was no further decrease in vision on follow up.Conclusion:To the best of our knowledge, this is the first report of clinically demonstrable macular toxicity in the form of macular atrophic changes and bull’s eye maculopathy associated with the use of cytarabine and daunorubicin. Early diagnosis and appropriate management of such cases is imperative to prevent further visual deterioration.
Highlights
The incidence of cytotoxic chemotherapy-related ocular toxicity is on the rise with the advent of newer agents and more aggressive combination regimens [1]
A 50-year-old man, who was diagnosed with Acute Myeloid Leukemia (AML M1), developed sudden decrease in vision in his left eye after three cycles of intravenous cytarabine and daunorubicin
Optic nerve toxicity associated with cytarabine and daunorubicin has been reported in rare instances [5, 6]
Summary
To the best of our knowledge, this is the first report of clinically demonstrable macular toxicity in the form of macular atrophic changes and bull’s eye maculopathy associated with the use of cytarabine and daunorubicin.
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