Abstract
Given the traditionally low CDAD (Clostridium difficile associated diarrhoea) prevalence in Switzerland, CDAD patients are not routinely contact-isolated in our institution. In light of the globally changing C. difficile epidemiology, we sought to determine our institutional CDAD rate and to detect possible hospital transmission by means of epidemiological linkage. We included every CDAD patient hospitalised in our institution, a tertiary-care hospital in eastern Switzerland, in 2009/2010. Patients with healthcare facility associated (HCFA) CDAD were grouped into cases with and without exposure to an infectious CDAD patient. Exposure was defined as sharing the room/ward with an infectious patient before symptom onset, either at the same time or within 30 days after discharge of the infectious patient. Molecular strain typing was not performed. We registered 141 CDAD episodes. Among them 108 were HCFA (associated with our institution), corresponding to an incidence of 2.3/10,000 patient days. Fifty-six percent (60/108) were exposed to an infectious CDAD patient, suggesting hospital transmission. The number of patients without exposure remained relatively stable, whereas presumably transmitted cases - often occurring within spatiotemporal clusters - showed high variability over time. Presumably transmitted cases were significantly older (p = 0.032) and more likely to have a Charlson score >1 (p = 0.001). In our setting, 56% of healthcare associated CDAD cases have been exposed to an infectious CDAD patient. In view of the clustering of these presumed hospital transmissions, we consider an intensification of our current infection control measures, mainly on wards with elderly and comorbid patients which are particularly prone to C. difficile transmission.
Highlights
Clostridium difficile associated diarrhoea (CDAD) is among the most common causes of nosocomial diarrhoea and is associated with increased morbidity and mortality in infected patients [1]
In our setting, 56% of healthcare associated CDAD cases have been exposed to an infectious CDAD patient
In view of the clustering of these presumed hospital transmissions, we consider an intensification of our current infection control measures, mainly on wards with elderly and comorbid patients which are prone to C. difficile transmission
Summary
Clostridium difficile associated diarrhoea (CDAD) is among the most common causes of nosocomial diarrhoea and is associated with increased morbidity and mortality in infected patients [1]. Exposure to infectious CDAD patients (and presumptive pathogen acquisition) has been identified as another risk factor for CDAD [5, 6], whereas primarily symptomless colonisation by C. difficile seems to be a protective factor against CDAD [7]. Current guidelines concerning infection control measures against C. difficile recommend contact precautions for all CDAD patients, including the use of gloves and gowns by healthcare workers and visitors [8]. These guidelines lack high-grade evidence and are often not universally implemented [9]. In settings with high CDAD prevalence and well implemented infection control measures, hospital-transmitted CDAD cases based on epidemiological and microbiological criteria (multilocus sequence typing, MLST) have been shown to account for only a maximum of 25% of CDAD cases [10]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have