Pressurized intraperitoneal aerosol chemotherapy (PIPAC) and systemic chemotherapy for peritoneal metastases of gastric cancer: open-label, single-arm, multi-center feasibility study

Abstract

Background: Peritoneum is among the most common sites of metastases in gastric cancer. Systemic chemotherapy is the current standard for peritoneal carcinomatosis (PC), although, the treatment results remain extremely poor. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a modern treatment modality for PC. Despite some encouraging preliminary results for PIPAC efficacy, it is still an investigational treatment. Furthermore, only very limited data exist for bidirectional treatment, which includes a combination of systemic chemotherapy and PIPAC.