Abstract
BackgroundSafety, environmental and economic setbacks are driving industries to find greener approaches to extract bioactive compounds from natural resources. Pressurized hot water extraction (PHWE) is among the solvent free and efficient methods for extracting bioactive compounds.ExperimentalIn this study, the suitability of PHWE for extracting bioactive compounds such as phenolics, hydrolysable tannins and flavonoids from Phyllanthus tenellus was investigated by UPLC-qTOF-MS.ResultsSolvent properties of water are significantly increased through imposing temperature at 121 °C and pressure at 15 p.s.i. Pressurized hot water extraction obtained 991-folds higher hydrolysable tannins than methanol extraction.ConclusionThe extraction yields of hydrolysable tannins with PHWE was almost double of absolute methanol extraction.
Highlights
Phyllanthus tenellus Roxb., an herbaceous plant belonging to the family of Euphorbiaceae, is closely related to the commonly known Phyllanthus niruri
The results suggest that pressurized hot water extraction can successfully be used for the extraction of P. tenellus bioactive compounds as the extraction yields of hydrolysable tannins with Pressurized hot water extraction (PHWE) was almost double of absolute methanol extraction
The results revealed that the solvent/polarity properties of water were significantly enhanced and PHWE managed to extract considerably higher amounts of flavonoids (42-folds higher than water at room temperature) and hydrosable tannins together with their catabolites (991-folds higher than water at room temperature)
Summary
Phyllanthus tenellus Roxb., an herbaceous plant belonging to the family of Euphorbiaceae, is closely related to the commonly known Phyllanthus niruri. Similar to P. niruri, it is known for its health benefiting properties. This plant is used to treat urolithiasis, inflammatory bowel disease, diabetes and hepatitis B [1]. The genus Phyllanthus is a rich source of phenolics and. Environmental and economic setbacks are driving industries to find greener approaches to extract bioactive compounds from natural resources. Pressurized hot water extraction (PHWE) is among the solvent free and efficient methods for extracting bioactive compounds. Experimental: In this study, the suitability of PHWE for extracting bioactive compounds such as phenolics, hydrolysable tannins and flavonoids from Phyllanthus tenellus was investigated by UPLC-qTOF-MS
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