Abstract
AbstractThe potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)‐epoxysuberosin, alosin, (–)‐meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)‐trachypleuranin A and (–)‐yuehgesin B. In addition, seselin, (+)‐epoxysuberosin, alosin, and (–)‐meranzin were found to inhibit NQO1 activity. Interestingly, (–)‐meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.
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