Pressure Overload Leads to Severe Concentric Hypertrophy in Adiponectin-Deficient Mice

Abstract

Adiponectin is a cardioprotective adipokine that is reduced in obesity and cardiovascular diseases. The role of adiponectin in the progression of left ventricle hypertrophy (LVH) and heart failure (HF) has not been elucidated. Transverse aortic constriction (TAC) (aorta tied using a 26G needle) has been used to induce pressure overload for 2 wks, resulting in LVH and LV chamber dilation in wild type (WT) mice, but yielding concentric LVH in adiponectin knockout (APN-/-) mice, comparable to the diastolic heart failure seen in insulin-resistant patients (Nat Med.