Abstract
The pressor response to angiotensin II infused intravenously was studied in 8 normal subjects and 44 patients with primary and secondary hypertension. The mean dose of angiotensin II required to increase diastolic blood pressure by 20 mm. Hg was significantly lower in 24 patients with essential hypertension than in control subjects and 11 patients with renovascular hypertension. Mean plasma renin activity in peripheral venous blood was similar in control subjects and patients with essential hypertension and significantly higher in patients with renovascular hypertension. The pressor dose of angiotensin II was directly correlated with peripheral plasma renin activity. However, norrnotensive control subjects and patients with essential hypertension with similar values of plasma renin activity exhibited markedly different sensitivity to angiotensin II. Further, the pressor response to norepinephrine and metaraminol paralleled that to angiotensin both in patient groups and in individual cases. The results suggest that the pressor response to angiotensin II in hypertensive patients is related not only to the level of circulating endogenous angiotensin but also to nonspecific hyperreactivity in essential hypertension and nonspecific hyporeactivity in renovascular hypertension.
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