Abstract
TNF-α is involved in regulation of herpes virus replication and dissemination, and varicella, herpes zoster and herpes labialis have been observed as adverse events during clinical trials with and in national registries for the use of etanercept in JIA, in some cases resulting in serious adverse events (saes).
Highlights
TNF-a is involved in regulation of herpes virus replication and dissemination, and varicella, herpes zoster and herpes labialis have been observed as adverse events during clinical trials with and in national registries for the use of etanercept in juvenile idiopathic arthritis (JIA), in some cases resulting in serious adverse events
Eighty-five (85) patients with JIA receiving etanercept in combination with MTX and 71 patients receiving MTX alone were enrolled at the Division of Rheumatology, Bambino Gesù Children’s Hospital, Rome, Italy
Crude incidence rates for herpes labialis were significantly higher among patients receiving etanercept/MTX (70 episodes in 15 patients) compared
Summary
TNF-a is involved in regulation of herpes virus replication and dissemination, and varicella, herpes zoster and herpes labialis have been observed as adverse events during clinical trials with and in national registries for the use of etanercept in JIA, in some cases resulting in serious adverse events (saes)
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