Abstract
The quest for the ideal valve substitute, namely, a valve requiring no anticoagulation and free from early valve degeneration with a good hemodynamic profile, remains unsolved despite continued research over the past 50 years. The present report describes a well-functioning aortic root homograft 32 years after implantation. It illustrates the potential longevity of implanted tissue valves and highlights the need to better understand the cellular and molecular physiology of heart valves as well as the mechanisms responsible for structural valve degeneration.
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