Preserved autoregulation of coronary flow after off-pump coronary artery bypass grafting: retrospective assessment of intraoperative transit time flowmetry with and without intra-aortic balloon counterpulsation.

Hiroyuki Nakajima,Mimiko Tabata,Kazuhiko Uwabe,Atsushi Iguchi,Hiroshi Niinami,Masahiro Ikeda,Toshihisa Asakura,Masaru Kambe

doi:10.1186/s13019-016-0550-8

Hiroyuki Nakajima, Mimiko Tabata + Show 6 more

Open Access

https://doi.org/10.1186/s13019-016-0550-8

Copy DOI

Abstract

BackgroundIntra-aortic balloon pumping (IABP) markedly increases graft flow after coronary artery bypass grafting (CABG) with cardiopulmonary bypass. We sought to delineate the effects of IABP on graft flow after off-pump CABG (OPCAB).MethodsThe clinical records of 32 patients (25 male, 7 female; mean age: 70 ± 9 years) who underwent OPCAB with IABP between January 2011 and May 2015 were retrospectively reviewed. Thirteen patients (41%) had a history of myocardial infarction, and 13 patients (41%) had a history of percutaneous coronary intervention. In total, there were 76 bypass grafts with 102 distal anastomoses. These included 50 in situ or pedicled grafts and 26 aortocoronary grafts. After completion of the anastomoses, the heart was positioned normally, and graft flow with IABP was measured using transit-time flowmetry under stable circulation. Then, IABP was turned off for 30 s to a few minutes, until graft flow was constant, for measurement of flow off IABP.ResultsThe angiographic patency rate was 100% (47/47). Overall, graft flow was 55 ± 36 ml/min on IABP and 53 ± 36 ml/min off IABP (p = 0.37). The pulsatility index was 4.1 ± 2.1 on IABP and 2.7 ± 1.5 off IABP (p < 0.001). There was no significant difference in graft flow between on and off IABP for aortocoronary bypass or in situ grafts. Graft flow was 57 ± 36 ml/min on IABP and 55 ± 37 ml/min off IABP (p = 0.41) in in situ grafts and 52 ± 34 ml/min on IABP and 49 ± 35 off IABP (p = 0.41) in aortocoronary grafts. Graft flow on IABP was more than 5 ml/min greater in 28 (37%) bypass grafts, and more than 5 ml/min lower in 20 (26%) bypass grafts.ConclusionIn contrast to previous reports for conventional CABG, graft flow after OPCAB was not necessarily increased by IABP, regardless of elevated diastolic arterial pressure. It is suggested that preserved autoregulation of coronary flow contributes to a lower impact on the heart and early functional recovery, and consequently, greater perioperative safety of OPCAB.

Highlights

Intra-aortic balloon pumping (IABP) markedly increases graft flow after coronary artery bypass grafting (CABG) with cardiopulmonary bypass
We examined the effects of intraaortic balloon pumping (IABP) on graft flow after off-pump CABG (OPCAB), and compared the effects with those after on-pump coronary artery bypass grafting (ONCAB) to determine the influence of cardiopulmonary bypass on flow regulation and the physiological nature of the coronary circulation after OPCAB
There was no significant difference in graft flow between on and off IABP for aortocoronary bypass or in situ grafts

Summary

Introduction

Intra-aortic balloon pumping (IABP) markedly increases graft flow after coronary artery bypass grafting (CABG) with cardiopulmonary bypass. Off-pump coronary artery bypass grafting (OPCAB) is beneficial for patients with systemic comorbidities, such as renal or lung disease, or aortic calcification, or in patients who are elderly. OPCAB was reported to have less impact than conventional on-pump coronary artery bypass grafting (ONCAB) on cardiac function as determined by cardiac enzyme release [1,2,3], and allowed earlier recovery of the myocardium after surgery [4, 5]. We examined the effects of intraaortic balloon pumping (IABP) on graft flow after OPCAB, and compared the effects with those after ONCAB to determine the influence of cardiopulmonary bypass on flow regulation and the physiological nature of the coronary circulation after OPCAB

Methods

Results

Discussion

Conclusion