Preserved attenuation of the N1-response to self-initiated relative to externally initiated sounds in patients with focal cerebellar lesions due to tumor resection in childhood

Abstract

Event Abstract Back to Event Preserved attenuation of the N1-response to self-initiated relative to externally initiated sounds in patients with focal cerebellar lesions due to tumor resection in childhood Torgeir Moberget1*, Pamela Bäss2, Stein Andersson3, Bernt Due-Tønnessen3, Aasta Heldal3 and Tor Endestad1 1 University of Oslo, Norway 2 Aalto University School of Science, Finland 3 Oslo University Hospital - Rikshospitalet, Norway Introduction: It has been suggested that a main function of the cerebellum is to generate temporally precise predictions about upcoming events. Such predictions play a crucial role in motor control, but might also explain cerebellar involvement beyond the motor system. For instance, reaction times are faster when the onsets of sensory stimuli are predictable and neural responses to sensory stimuli are modulated by stimulus predictability (Nobre, 2001). Using event-related potentials, several groups have demonstrated a markedly reduced auditory N1-response to tones initiated by the subject (through a button press) relative to physically identical tones played back to the subject in the same sequence (Schafer & Marcus, 1973; Bäss et al., 2008; Ford et al., 2007). If the cerebellum is involved in generating predictions about upcoming events, one might expect reduced attenuation of the N1 to self-initiated (predictable) tones in patients with cerebellar lesions. Methods: We conducted a modified version of this experiment – with self- and externally initiated sounds presented within the same auditory stream (Bäss et al., accepted) – in 12 adult patients with focal cerebellar lesions due to tumor resection in childhood or adolescence and 9 healthy matched controls. Results: Contrary to our predictions, we observed robust N1 suppression in both groups, and no significant difference between cerebellar patients and healthy controls. Conclusion: The present findings suggest that the cerebellar areas affected in our patient group (maximal lesion overlap near the midline) are not part of the neural circuitry necessary for the suppression of self-generated auditory stimuli. Keywords: N1-response, Perception Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neurophysiology of Sensation and Perception Citation: Moberget T, Bäss P, Andersson S, Due-Tønnessen B, Heldal A and Endestad T (2011). Preserved attenuation of the N1-response to self-initiated relative to externally initiated sounds in patients with focal cerebellar lesions due to tumor resection in childhood. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00475 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Torgeir Moberget, University of Oslo, Oslo, Norway, torgeir.moberget@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Torgeir Moberget Pamela Bäss Stein Andersson Bernt Due-Tønnessen Aasta Heldal Tor Endestad Google Torgeir Moberget Pamela Bäss Stein Andersson Bernt Due-Tønnessen Aasta Heldal Tor Endestad Google Scholar Torgeir Moberget Pamela Bäss Stein Andersson Bernt Due-Tønnessen Aasta Heldal Tor Endestad PubMed Torgeir Moberget Pamela Bäss Stein Andersson Bernt Due-Tønnessen Aasta Heldal Tor Endestad Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.