Abstract

Introduction We studied the evolution of the liver graft with preservation in Celsior (CS) compared with University of Wisconsin solution (UW). Material and methods A randomized prospective clinical study in 80 liver transplants (OLTs) from May 2001 to October 2003, compared CS (group I; n = 40) and UW (group II; n = 40). The characteristics of the donors were homogeneous, with no significant differences in 15 variables. CS was perfused with 4 L through the aorta, 2 L through the portal vein, and 1 L, through the portal vein on the back table; and the UW, as 3 L, 2 L, and 1 L, respectively. All OLTs were performed using the piggyback technique. Results Group I experienced reperfusion syndrome ( n = 2; 5.9%), primary graft nonfunction ( n = 0); vascular complications ( n = 0); biliary anastomosis stenosis ( n = 8; 22.9%), intensive care unit (ICU) days ( n = 4.1 ± 1), death within 30 days ( n = 1; 3.1%). The patient and graft survivals at 1, 3, 6, 12, and 24 months were 93.7%, 93.7%, 90.2%, 85.7%, 85.7%, and 94.3%, 88.5%, 85.2%, 78%, 78%, respectively. For group II; the reperfusion syndrome occured in 6 patients (17.6%); primary graft nonfunction ( n = 0); vascular complications ( n = 0), biliary anastomosis stenosis ( n = 3; 8.6%), ICU days ( n = 4.9 ± 2.4) and death within 30 days ( n = 1; 3.1%); The patient and graft survival at 1, 3, 6, 12, and 24 months were 96.9%, 93.5%, 89.8%, 79.8%, 79.8% and 94.3%, 88.3%, 84.9%, 75.5%, 66.1%, respectively. Conclusions CS offers the similar safety to UW for preservation of liver grafts within these ischemia times.

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