Presepsin: Early Biomarker in Diagnosis of Sepsis in Emergency Department

Abstract

Objective: Sepsis is a common syndrome with devastating implications for health care systems worldwide. Biomarkers may play an important role in highlighting the presence, absence or severity of sepsis. Materials and methods: This study is an retrospective study, performed on patients with suspected sepsis (81 patients) from a total of 10,483 patients who where presented themselves in the Emergency Department-Sf. Spiridon Hospital-Iasi between 01.09.2014-30.10.2014. The study aims was to establish the following aspects: determining the validity of presepsin as a biological diagnostic and prognostic marker of sepsis and mortality at 30 days after presentation moments in the Emergency Department. Results: The mean age of patients was 64.52 years. Determination of presepsin sensitivity in early diagnosis of sepsis was calculated by generating the ROC curve, the AUC values (Area Under the Curve) obtained were: AUC=0.709, with a standard error of 0.065 for sepsis prediction; AUC=0.866, with a standard error of 0.080 for severe sepsis; AUC=0.864, with a standard error of 0.053 in the case of septic shock. The AUC calculated for presensin susceptibility to mortality was 0.764, with a standard error of 0.062. Conclusion: Presepsin, determined by using quantitative dosing methods, can be of real use in the staging of patients diagnosed with sepsis, and may be indicative of initiating intensive care to prevent the onset of septic shock. Presepsin may be an early marker of mortality in the septic patient.