Presepsin as a marker of sepsis and severe pneumonia

Abstract

The aim of this study was to evaluate a role of presepsin for diagnosis of severe pneum o nia and sepsis . Methods . The study involved 54 patients with pneumonia , sepsis , and ot h er inflammatory diseases , aged 17 to 77 years . Presepsin level was measured in all the patients using immunochemiluminescent analysis . Before entering the study , all patients were treated with antibacterials in other healthcare institutions . Results . Presepsin level was 3083 . 8 ± 598 . 1 pg / mL in patients with pneumogenic sepsis ( n = 14 ) , 2867 . 4 0 ± 503 . 64 pg / mL in patients with abdominal sepsis ( n = 16 ) , and 873 ,00 ± 132 . 92 pg/mL in patients with other inflammatory diseases ( n = 8 ). Preseptin level was 5430 . 5 0 ± 721 . 97 pg/mL in p a tients with severe pneumogenic sepsis ( n = 4 ) compared to 1471 . 7 ± 221 . 8 pg/mL in those with non-severe pneumogenic sepsis ( n = 6; p < 0 . 05 ) and 642 . 0 0 ± 140 . 59 pg/mL in patients with severe pneumonia ( n = 10 ) compared to 231 . 3 0 ± 54 . 26 pg/mL in p a tients with non-severe pneumonia ( n = 6; p < 0 . 05 ). Conclusion . A high level of presepsin could be used as a marker of active infection as it reflects severity of pneumonia and sepsis . Persi s tent high level of presepsin under antibiotic treatment could indicate failure of the therapy . Therefore , presepsin could be used as a reliable diagnostic marker which helps to determine severity of pneumonia and sepsis , and therapeutic e f ficacy .