Abstract
BackgroundPheochromocytoma and paraganglioma are rare neuroendocrine tumors of the chromaffin tissue, which may produce catecholamines. The aim of our study was to analyze the clinical and para-clinical aspects as well as the therapeutic and evolutionary aspects of pheocromocytomas and paragangliomas based on a series of 40 cases.MethodsOur retrospective population-based research study includes 40 patients. Then, a statistical analysis was carried out using the SPSS software (version21).ResultsOur study involves 40 patients, including 23 women (57, 5%) and 17 men (42,5%). The mean age at the time of the diagnosis was 43.8 ± 16.8 years. The circumstances of the discovery were mainly characterized by adrenal incidentaloma and hypertension. The biological diagnosis was based on the dosage of urinary metanephrines and plasma-free metanephrines in, respectively, 61.5% and 18% of cases. A computerized tomography scan and/or a magnetic resonance imaging scan could help to locate the tumor in 100% of cases. Our series includes 3 cases of bilateral pheochromocytoma, 3 cases of paragangliomas and 1 case of malignant pheochromocytoma, while a hereditary form was retained in 3 patients. In fact, thirty-two patients were operated; cure was clinically labeled in 100% and biologically in 87.5% of patients.ConclusionsThe main points for improvement that our study has revealed are; a patient follow-up after surgery, which was not always regular, and an insufficient screening for genetic diseases associated with pheochromocytomas and paragangliomas.
Highlights
Pheochromocytoma and paraganglioma are rare neuroendocrine tumors of the chromaffin tissue, which may produce catecholamines
Pheocromocytomas (PHEO) are tumors that arise from chromaffin cells within the adrenal medulla, whereas paragangliomas (PGL) arise from extra-adrenal chromaffin cells of the sympathetic or parasympathetic paravertebral ganglia in the chest, abdomen, and pelvis
Through a retrospective study, we propose to analyze the clinical and para-clinical aspects as well as the therapeutic and evolutionary aspects of pheocromocytomas and paragangliomas based on a series of 40 cases
Summary
Pheochromocytoma and paraganglioma are rare neuroendocrine tumors of the chromaffin tissue, which may produce catecholamines. The aim of our study was to analyze the clinical and para-clinical aspects as well as the therapeutic and evolutionary aspects of pheocromocytomas and paragangliomas based on a series of 40 cases. Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors of chromaffin cells that produce catecholamines [1]. PGL may arise from the chromaffin cells of the parasympathetic ganglia of the According to the current literature, the estimated prevalence of PPGL ranges from 0.1 to 0.6% of patients with hypertension in a general outpatient clinic [4, 5]. Through a retrospective study, we propose to analyze the clinical and para-clinical aspects as well as the therapeutic and evolutionary aspects of pheocromocytomas and paragangliomas based on a series of 40 cases
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