Abstract
CD30, a member of the TNF/NGF receptor superfamily, is firstly thought to be a specific marker for Hodgkin's and Reed-Sternberg's cells. Recent studies revealed that its function is not restricted to a tumor marker of Hodgkin and Reed-Sternberg's cells. It might play an important role in the immune system and the cascade which would lead to the apoptotic phenomenon. Nowadays, the expression of CD30 is thought to have relation to various diseases, not only Hodgkin's disease and anaplastic large cell lymphoma (ALCL), but also atopic diseases and AIDS. This comes from the fact that CD30 expression has correlate to the Th2 cytokine production.The pathway of CD30/CD30L signal is now being revealed, which involves the TNF receptor associated factor (TRAF)-1, TRAF-2, TRAF-3, similar to other member of this family. However, the exact role of CD30 and its regulatory mechanism for the expression is not clear yet. In this review we summarized the latest information of CD30.
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Schedule a callMore From: The journal of the Japanese Society of Lymphoreticular Tissue research
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