Abstract

Despite the fact that bacterial infections play a far larger part in human affairs than does invasion by protozoa and other animal parasites, most of the investigative work heretofore done on the possibility of specific chemical disinfection has concerned the latter group of invaders. When we think of specific chemotherapy, we recall malaria and quinin; trypanosomiasis and the several chemicals that destroy the parasites involved; amebic dysentery and emetin; bilharziasis and antimony and potassium tartrate; spirilloses and the arsphenamins; but most of us do not associate successful specific chemotherapy with bacterial infections. Theoretically, at least, we have the right to expect even more ready attack on bacteria than on protozoa, since the former are less closely related to mammalian organisms than the protozoa, and in chemotherapy we are seeking for cell poisons that will select the parasite rather than the host.<sup>1</sup>Up to the present time, however, we have no

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