Abstract
It is known that the human exocrine pancreas responds to secretin stimulation more than does VIP, a structurally related peptide. We looked for the receptors for those polypeptides in a human pancreatic cancer cell line grown in culture and in nude mice. By analysing the cAMP responses and the 125I-VIP binding we found VIP receptors with a K D of 1.5 10 −9 M. Secretin stimulates the adenylate cyclase through the VIP receptor sites with a K D of 1.7. 10 −6 M. We noted also that during cell proliferation in culture there was about a 5 fold increase of the cAMP response to VIP.
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