Abstract
The presence of toxic substances which inhibit erythropoiesis in uremic sera is still undetermined. We examined the effect of aceton-methylalcohol extracts of serum of nephrectomized rabbits with uremia on the erythropoiesis. The percentage red cell iron utilization was markedly reduced in nephrecto-mized rabbits with uremia. The administration of aceton-methylalcohol extracts of uremic rabbit serum resulted in a marked decrease of percentage red cell iron utilization in rats which fasted for 32 hours. However, the administration of aceton-methylalcohol extracts of normal rabbit serum did not result in any decrease of percentage red cell iron utilization in fasting rats. The administra-tion of uremic extracts caused a marked shortening of the reticulocyte life span in colehicinized rats. The percentage of erythroblasts labeled with H3-thymidine in vitro was markedly reduced in uremic nephrectomized rabbits. The administration of uremic extracts resulted in a decrease of the in vivo incorporation of H3-thymidine in erythroblasts with their increased abortion in rats which starved for 32 hours. These results demonstrate the presence of toxic substances which inhibit erythropoiesis in uremic rabbit serum.
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