Presence of the vim-2 gene of Pseudomonas aeruginosa carbapenem resistance

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes infection in immunocompromised patients. Pseudomonas aeruginosa can cause severe acute and chronic infections in patients on ventilators and patients with burns, surgery, diabetic foot ulcers, and catheterization. vim-2 gene distributes metallo-β-lactamase with a broad spectrum of substrates against penicillins, cephalosporins, cefamycins, and carbapenems. Therefore, an attractive drug target for the treatment of β-lactam-resistant infections. This study aims to know the presence of the vim-2 P. aeruginosa carbapenem resistance gene. Pseudomonas aeruginosa is the most common microorganism that causes infection in the community and hospitals. Resistance of P. aeruginosa to various antibiotics is an increasingly common overuse or inappropriate use. vim-2 gene is of high clinical relevance due to its wide distribution and broad substrate range and therefore represents an important drug target for treating antibiotic-resistant infections. Based on the literature review, a molecular examination of the vim-2 gene is critical to be a reference in selecting appropriate antibiotics in addition to phenotypic study.