Abstract
Although the inositol 1,4,5-triphosphate (IP 3)-induced nuclear Ca 2+ release has been shown to play key roles in nuclear functions, the presence of IP 3 receptor (IP 3R)/Ca 2+ channels in the nucleoplasm has not been found. Recently, the IP 3R/Ca 2+ channels were reported to exist in the nucleoplasmic reticulum structure, an extension of the nuclear envelope. Here we investigated the potential existence of the IP 3Rs in the nucleoplasm and found the presence of all three IP 3R isoforms in neuroendocrine and non-neuroendocrine cells. The IP 3Rs were widely scattered in the nucleoplasm, localizing in both the heterochromatin and euchromatin regions.
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