PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION

Abstract

Introduction: It`s well known that the periodontitis is а complex disease initiated by bacteria, but modified by environmental factors and the host response. As any other chronic disease, the periodontal disease is influenced by the individual predisposition of the patient to develop the specific symptoms. The increasing number of studies in the area of the genetic factors and mechanisms of the patient to develop the specific condition is leading to the need for certain polymоrphism’s to be studied in details for the Bulgarian population. Aim: The recent study aims to identify the presence of SNP of IL-17F in the Bulgarian population. Materials and methods: In the study, 40 patients with periodontitis stage II, III and IV and 10 healthy control subjects were taking part. The age of the subjects varied between 23 and 75 with an average value of 46 years. Clinical and radiographic methods to establish the basic periodontal parameters were used. Laboratory methods were performed by means of Real-Time PCR for determination of SNP of Interleukin 17F (IL-17F) (-7488C/T rs_763780). The statistic data was processed with PCA – IBM SPSS Statistics Version 21. From all of the patients, informed consent was taken. Results: The recent study collected information about the dominating genotype when studying SNP of IL-17 F for patients with periodontitis. The presence of two genotypes was established – genotype TT (92%) and genotype CT (8%). We have established specific tendencies about the distribution of major parameter for diagnosis of periodontitis such as BoP and BL/Age in both groups. The individual host susceptibility can be used as a diagnostic parameter leading to the development of screening methods in order suspectable individuals to be found. Conclusion: The study has contributed to clarifying the genetic characteristic of the tested subject. The results confirmed the data from different studies that aim to research the genetic polymorphism of IL-17F in relation to periodontitis.