Abstract
Sarcopenia has been associated with poor clinical outcomes in several diseases. Herein, the clinical results of balloon kyphoplasty (BKP) for acute osteoporotic vertebral fracture (OVF) treatment were assessed and compared between sarcopenia and non-sarcopenia patients. Sixty patients who underwent BKP for treatment of acute OVF with poor prognostic factors between April 2016 and September 2017 and were assessed for sarcopenia were enrolled. Clinical results (back pain on visual analogue scale [VAS]; short-form [SF] 36; vertebral deformity; activities of daily living levels; and incidence of adjacent vertebral fractures) were compared between the two groups at 6 months post-BKP. Data analysis revealed that back pain on VAS, SF-36 scores, and vertebral deformity improved from baseline to 6 months after BKP. Thirty-nine patients (65.0%) were diagnosed with sarcopenia and demonstrated a lower body mass index (21.2 vs. 23.3 kg/m2, p = 0.02), skeletal muscle mass index (5.32 vs. 6.55 kg/m2, p < 0.01), hand-grip strength (14.7 vs. 19.2 kg, p = 0.01), and bone mineral density of the femoral neck (0.57 vs. 0.76 g/cm2, p < 0.01) than those of patients without sarcopenia. However, no significant differences were observed in the clinical results between these groups. Therefore, BKP’s clinical results for the treatment of acute OVF are not associated with sarcopenia.
Highlights
Sarcopenia has been associated with poor clinical outcomes in several diseases
Balloon kyphoplasty (BKP) for acute osteoporotic vertebral fracture (OVF) with poor prognostic factors was considered superior to conservative management[19]; no reports indicate that balloon kyphoplasty (BKP) intervention would be effective for patients with sarcopenia
We hypothesized that the clinical results of BKP for acute OVF with poor prognostic factors differ between patients with and without sarcopenia, and like various other diseases, patients with sarcopenia would have poorer outcomes when compared to patients without sarcopenia
Summary
The clinical results of balloon kyphoplasty (BKP) for acute osteoporotic vertebral fracture (OVF) treatment were assessed and compared between sarcopenia and non-sarcopenia patients. Most patients with acute OVF responded well to conservative treatment[14]; some patients with acute OVF reported poor outcomes such as persistent back pain and a decline in the level of activities of daily living (ADL) due to the delayed union of O VF15,16. We hypothesized that the clinical results of BKP for acute OVF with poor prognostic factors differ between patients with and without sarcopenia, and like various other diseases, patients with sarcopenia would have poorer outcomes when compared to patients without sarcopenia. This study aimed to compare the clinical results of BKP for acute OVF with poor prognostic factors between patients with and without sarcopenia
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