Abstract
Takahashi, K., M. Sone, F. Satoh, O. Murakami, K. Totsune, H. Tanji, N. Sato, H. Ito and T. Mouri. Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid. Peptides 18(3) 459–461, 1997.—The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 ± 3.1 pmol/l (mean ± SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin(1–52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.
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