Abstract
Vasopressin (VP) and oxytocin (OT) may be synthesized in a common precursor with neurophysins (NP). We postulated that precursors may be more abundant in the neurohypophysis of the immature rat. By RIA, we found : There was a molar excess of NP early in gestation, and later a molar excess of VP. Bioassay of VP from the fetus correlated with RIA values. By gel filtration a big form pf VP was found which varied with the method of extraction. With one system > 85 % of VP from the fetus was in the big form while < 15 % of VP from the adult was big. The relationship of big VP to NP is not clear. The developing rat is a good model for the study of precursor hormones.
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