Abstract
The hypocalcemic activity of the ultimobranchial gland (UBG) in the snake, Rhabdophis tigrinus tigrinus, was examined in a bioassay using young Sprague-Dawley rats. Crude extracts of the UBG showed a hypocalcemic potency. In general, the response showed a dose-response relationship. The activity of one UBG nearly corresponds to that of 10 mU (MRC) of salmon calcitonin. Crude extracts of the snake thyroid gland did not cause any detectable hypocalcemic response even with a high dose.
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