Presence and functions of immune components in the tumor microenvironment.

Abstract

There is ample evidence that alterations in oncogenes and tumor suppressor genes are causally involved in malignant transformation (1-3). In addition to alterations in these class I cancer genes (4), changes in the expression of numerous genes whose DNA was not altered i.e. class II cancer genes (4), play crucial roles in tumorigenesis and in tumor progression. Among the important class II cancer genes are proteases, angiogenic factors and angiogenesis inhibitors, cytokines and chemokines and their receptors as well as various adhesion molecules (5-8). It seems that class II cancer genes play a more significant role in the process of tumor progression than in cellular transformation and primary tumorigenesis (4).KeywordsTumor MicroenvironmentCancer GeneBoron Neutron Capture TherapyAdoptive ImmunotherapyIsolate Limb PerfusionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.