Abstract
The formulations of prescriptions for CAPD and PD plus are based on the theoretical constructs of equilibration dialysis and automated PD. There is good correlation between the predicted clearances and net ultrafiltration and those observed in clinical practice, particularly for patients with average peritoneal transport. Higher dialysate flows prescribed during APD to enhance small solute clearances and net ultrafiltration often result in reduced sodium removal due to sodium sieving. Sodium sieving can be minimized with APD through optimal prescriptions. The evidence supports the use of PD plus when adequacy targets cannot be achieved with CAPD.
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