Abstract
<p><strong><em>Introduction</em></strong><em>:<strong> </strong></em><em>Our aim was to investigate the prescription patterns of antidepressant in the southern Israel during the years 2000 to 2005, before and after the FDA black box warning issued regarding the prescription of antidepressants in children. </em><em></em></p><p><strong><em>Patients and methods</em></strong><em>:</em><em> </em><em>A cross sectional study. Data regarding prescription of anti-depressant drugs was examined retrospectively. All information was obtained from the computerized databases of the Clalit Health care services, southern county. Data was analyzed by using descriptive statistics, and analytical statistics. Multi-variate analysis was performed when applicable.</em></p><p><strong><em>Results</em></strong><em>: When comparing the prescription rate of fluoxetine and fluvoxamine versus other SSRI’s included in the health agencies warnings during the years mentioned, there was a gradual increase in the percentage of the other SSRI’s until 2003 from 12.2% in 2000 to 64.2% in 2003 and then a reversal of this trend from 51.9% in 2004 to 47.8% in 2005.</em><em></em></p><strong><em>Discussion and conclusions</em></strong><em>: This study shows that the CSM advice has not had a significant effect in reversing the rising prevalence of antidepressant prescribed to children and adolescents in primary care. It has however changed the choice of antidepressant medication chosen within the group of SSRI’s.</em>
Highlights
Our aim was to investigate the prescription patterns of antidepressant in the southern Israel during the years 2000 to 2005, before and after the FDA black box warning issued regarding the prescription of antidepressants in children
This study shows that the Committee on Safety of Medicines (CSM) advice has not had a significant effect in reversing the rising prevalence of antidepressant prescribed to children and adolescents in primary care
It has changed the choice of antidepressant medication chosen within the group of Selective serotonin reuptake inhibitors (SSRI’s)
Summary
Our aim was to investigate the prescription patterns of antidepressant in the southern Israel during the years 2000 to 2005, before and after the FDA black box warning issued regarding the prescription of antidepressants in children. Discussion and conclusions: This study shows that the CSM advice has not had a significant effect in reversing the rising prevalence of antidepressant prescribed to children and adolescents in primary care. It has changed the choice of antidepressant medication chosen within the group of SSRI’s. The most likely reason underlying the age of onset of suicide is that depression and exposure to drugs and alcohol, two significant risk factors for suicide are rare in very young children and becomes prevalent only later adolescence (Gould et al, 2003). Completed suicide is more common in 15- to 24-year old males than females in North America, Western Europe, Australia, and New Zealand. Disruptive behavior disorder (DBD), and substance use disorder (SUD) are the three types of disorders that are most prevalent within the adolescent suicide victim population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
