Abstract
My comment addresses points raised in the recent Pediatrics article by Coon et al titled “Update on Pediatric Overuse”1. The section of the article in question is titled “Antidepressants for Adolescents Are Determined to Be Ineffective and Possibly Harmful in Reanalysis of a Pivotal Trial.” This section highlights the recent “Restoring Study 329”, which raises major methodological concerns about an important original paroxetine and imipramine trial performed in the mid-late 1990s (Study 329). Coon et al conclude that the “current widespread use of antidepressants in adolescents may have been driven in part by misleading results from the initial [Study 329] trial … E-mail: brian.pitts{at}ucdenver.edu
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