Abstract
Extracts from some plants were screened for bioactive properties based on ethnopharmacolgical information on their potential as antitrypanosomal agent using brine shrimp lethality assay. After 24 h of exposure, the results of the experiment, which examines the effect of plant type, concentration effect and the interaction of the two factors were significant (P 0.05) when their mean separations of percentage mortality to PM values obtained for Khaya senegalensis, Aristolochia albida, Butryrospermum paradoxium and Prosopis africana were compared. This preliminary result suggest that these plants with promising bioactivity may possess component that may provide the chemical lead towards the discovery of new generation trypanocides that are more potent and less toxic than the currently available and marketed trypanocidal drugs. Key words: Antitrypanosomal agent, brine shrimp, lethality bioassays, bioactivity, and medicinal plant extract.
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