PReS13-SPK-1592: Pediatric aspects of antiphospholipid syndrome

T Avcin

doi:10.1186/1546-0096-11-s2-i13

Abstract

The antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disease characterized by thromboembolic events, pregnancy morbidity, hematologic, dermatologic, neurologic and other manifestations in the presence of elevated titers of antiphospholipid antibodies (aPL). In recent years, APS has been increasingly recognized in various pediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way.

Highlights

The antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disease characterized by thromboembolic events, pregnancy morbidity, hematologic, dermatologic, neurologic and other manifestations in the presence of elevated titers of antiphospholipid antibodies
A retrospective study with longitudinal follow-up of an unselected group of children who tested positive for at least one aPL subtype was conducted for assessment of the prevalence of clinical features associated with aPL in children
Associated non-thrombotic clinical manifestations included hematological manifestations (39%), skin disorders (19%) and non-thrombotic neurological manifestations (16%)

Summary

Introduction

The antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disease characterized by thromboembolic events, pregnancy morbidity, hematologic, dermatologic, neurologic and other manifestations in the presence of elevated titers of antiphospholipid antibodies (aPL). APS has been increasingly recognized in various pediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way

Methods

Results

Discussion