Abstract
Systemic Lupus Erythematosus (SLE) is a chronic, multisystem autoimmune disease that is the result of the interaction between genetic and environmental factors. Specific genes have been found to be related to the development of SLE and also single nucleotide polymorphisms (SNPs) have been associated to this condition. Although patients with pediatric-onset SLE (pSLE) and adult-onset SLE (aSLE) differ in disease presentation, activity, and outcomes, all studies to date have not found any specific or unique set of genes in pSLE compared to aSLE. Moreover, it has been shown that the frequency of genes in these two SLE populations is the same. However, is possible that an increased genetic load may explain the earlier onset and more severe disease seen in pSLE as compared to aSLE patients.
Highlights
Systemic Lupus Erythematosus (SLE) is a chronic, multisystem autoimmune disease that is the result of the interaction between genetic and environmental factors
Inclusion criteria: SLE patients who are followed at the participating centers and who meet at least 4 of 11 ACR classification criteria for this disease are eligible for study
We will determine a genetic score for each patient as explained as follow: 1. Simple count: protective single nucleotide polymorphisms (SNPs) and susceptibility SNPs 2
Summary
Systemic Lupus Erythematosus (SLE) is a chronic, multisystem autoimmune disease that is the result of the interaction between genetic and environmental factors. PReS-FINAL-2355: Comparison of pediatric and adult SLE genetic load Specific genes have been found to be related to the development of SLE and single nucleotide polymorphisms (SNPs) have been associated to this condition.
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