Abstract
Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is a multifaceted auto inflammatory syndrome which was initially described in persons of Irish-Scottish ancestry and in ethnic groups of northern European descent. To date, more than 70 mutations have been described. Since then, it has been described in other ethnicities. There have been few reports of from Asia, 11 cases have been described from Japan, and only one case of TRAPS has been described in an Arab child from Israel (1-8).There are no cases of TRAPS that have been described from Gulf Arab states.
Highlights
Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is a multifaceted auto inflammatory syndrome which was initially described in persons of Irish-Scottish ancestry and in ethnic groups of northern European descent
R92Q is a nonstructural gene mutation with low disease penetrance resulting in a mild disease course in patients with TRAPS (9)
We present 2 sisters with homozygous R92Q mutation presenting with different clinical disease course, a moderate and severe course which is unusual
Summary
Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is a multifaceted auto inflammatory syndrome which was initially described in persons of Irish-Scottish ancestry and in ethnic groups of northern European descent. More than 70 mutations have been described. Since it has been described in other ethnicities. There have been few reports of from Asia, 11 cases have been described from Japan, and only one case of TRAPS has been described in an Arab child from Israel (1-8).There are no cases of TRAPS that have been described from Gulf Arab states
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