Abstract
Systemic onset juvenile idiopathic arthritis (SoJIA) shows properties of autoinflammatory disease, and requires the presence of arthritis and fever for diagnosis. The pro-inflammatory proteins MRP8/14 (S100A8/9) and S100A12 are biomarkers which have been shown to detect ongoing subclinical disease activity in patients with clinical remission. We compared the MRP8/14 (S100A8/9) and S100A12 biomarker profile of patients in the AID-NET (German Auto-inflammatory Disease Network) register to further provide evidence for the usefulness of measurement of these biomarkers.
Highlights
Systemic onset juvenile idiopathic arthritis (SoJIA) shows properties of autoinflammatory disease, and requires the presence of arthritis and fever for diagnosis
The AID-Net register, which includes patients with SoJIA diagnosed according to ILAR criteria, was searched for patients with clinically defined remission and flare episodes
Patients presenting with episodes of flare had significantly higher mean S100A12 values compared with patients in remission (mean 2,895 ng/ml vs 575 (0-6,220) ng/ml, respectively, p- < 0.01)
Summary
Systemic onset juvenile idiopathic arthritis (SoJIA) shows properties of autoinflammatory disease, and requires the presence of arthritis and fever for diagnosis. The proinflammatory proteins MRP8/14 (S100A8/9) and S100A12 are biomarkers which have been shown to detect ongoing subclinical disease activity in patients with clinical remission. We compared the MRP8/14 (S100A8/9) and S100A12 biomarker profile of patients in the AID-NET (German Auto-inflammatory Disease Network) register to further provide evidence for the usefulness of measurement of these biomarkers
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